Aging Research in Yeast - download pdf or read online

By Michael Breitenbach, S. Michal Jazwinski, Peter Laun

This quantity contains contributions through the top specialists within the box of yeast getting older. Budding yeast (Saccharomyces cerevisiae) and different fungal organisms supply versions for getting older study which are appropriate to organismic getting older and to the getting older techniques happening within the human physique. Replicative getting older, within which in basic terms the mum phone a while whereas the daughter mobilephone resets the clock to 0 is a version for the getting older of stem mobile populations in people, whereas chronological getting older (measured by means of survival in desk bound part) is a version for the getting older procedures in postmitotic cells (for example, neurons of the brain). such a lot mechanisms of getting older are studied in yeast. between them, this publication discusses: mitochondrial theories of getting older, emphasizing oxidative tension and retrograde responses; the position of autophagy and mitophagy; the connection of apoptosis to getting older approaches; the function of uneven segregation of wear in replicative getting older; the function of replication pressure; and the function of the cytoskeleton in getting older. smooth tools of yeast genetics and genomics are defined that may be used to look for aging-specific services in a genome-wide impartial style. The similarities within the pathology of senescence (studied in yeast) and of melanoma cells, together with genome instability, are examined.

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Therefore the authors proposed that the association of Yap1p with Skn7p in the nucleus is a prerequisite for Skn7p phosphorylation and activation of oxidative stress response genes. Msn2/Msn4p The common set of genes involved in the general stress response is mainly regulated by the transcription factors Msn2p and Msn4p (Msn2/4p) (Causton et al. 2001; Gasch et al. 2000). The phosphorylated Msn2/4p transcription factors are localized in the cytoplasm during optimal growth conditions (Beck and Hall 1999; Gorner et al.

5). There is no enzyme known that can detoxify the hydroxyl radical, which reacts very rapidly with the nearest molecule and is therefore unlikely to accumulate in cells. The superoxide radical anion is removed by dismutation to hydrogen peroxide and oxygen catalysed by superoxide dismutases (SODs). Saccharomyces cerevisiae encodes two SOD enzymes, the more abundant Cu/Zn-containing Sod1p is located mainly in the cytoplasm, but a small proportion is also transported to the inter-membrane space of the mitochondrion.

2002). Damage to amino acids leads to formation of hydroxylated derivatives and oxidation of aromatic amino acid residues can produce reactive phenoxy radicals (Aeschbach et al. 1976; Fu et al. 1995). FeS-proteins are very susceptible to O•− 2 , as evidenced by the methionine and lysine auxotrophy of the double sod1 sod2 mutant lacking superoxide dismutase (SOD) activity (Liu et al. 1992). Hydrogen peroxide also leads to reversible oxidation of reactive cysteine residues in some proteins to form disulphides or sulfenic acid residues, or irreversible oxidation to sulphinic or sulphonic acids.

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