By L. Robert, T. Fulop, T. Fulop
Getting older encouraged loads of theories attempting to rationalize the getting older procedure universal to all dwelling beings. during this book an important environmental and intrinsic mechanisms eager about the getting older method and in its pathological effects are reviewed. in addition theoretical and experimental proof of an important theoretical components in accordance with Darwinian evolution, mobile getting older, position of mobilephone membranes, loose radicals and oxidative techniques, receptor-mediated reactions, the extracellular matrix and immune features in addition to an important environmental and intrinsic mechanisms excited by the getting older strategy and in its pathological results are mentioned. those shows of theories and similar experimental evidence provide an international evaluation of latest innovations of the biology of the getting older technique and are of crucial studying not just for experts during this box but in addition for practitioners of medical, clinical, social and experimental sciences.
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Extra resources for Aging: Facts and Theories
18 Marcotte R, Lacell C, Wang E: Senescent ﬁbroblasts resist apoptosis by downregulating caspase-3. Mech Ageing Dev 2004; 125:777–783. 19 Chen QM, Prowse KR, Tu VC, Purdom S, Linskens MH: Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated ﬁbroblasts. Exp Cell Res 2001; 265: 294–303. 20 Magalhaes JP, Chainiaux F, de Longueville F, Mainfroid V, Migeot V, Marcq L, Remacle J, Salmon M, Toussaint O: Gene expression and regulation in H2O2-induced premature senescence of human foreskin ﬁbroblasts expressing or not telomerase.
This was disregarded claiming that there are multiple pathways to cell senescence. Since it was thought that aging favors malignant transformation, speculations were made to ﬁnd a relationship between ‘cell senescence’ and cancers, which led to several paradoxes. The contradictions and paradoxes should be cleared to reestablish logic and order in the ﬁeld and understand its relevance for human aging. © 2014 S. Karger AG, Basel The Concept of Aging of Proliferative Cells The study of aging of proliferative cells was initiated by the work of Hayﬂick and Moorhead  who proposed that the loss of the division potential of human ﬁbroblasts through proliferation in vitro is an expression of aging at the cellular level.
20 Le Bourg E: Predicting whether dietary restriction would increase longevity in species not tested so far. Ageing Res Rev 2010;9:289–297. 21 Medawar PB: An Unsolved Problem in Biology. London, HK Lewis, 1952. 22 Williams GC: Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957;11:398–411. 23 Kirkwood TBL: Understanding ageing from an evolutionary perspective. J Intern Med 2008; 263: 117– 127. 24 Austad SN: Why We Age. New York, John Wiley and Sons, 1997. 25 Corder EH, Saunders AM, Stritmater WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families.