By Gadasina L.V.
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1991). Analysis of Human Genetic Linkage. Johns Hopkins University Press, Baltimore, MD. S. (2003). The Statistical Evaluation of Medical Tests for Classification and Production. Oxford University Press, London. R. (1991). A nonparametric method for dealing with mis-measured covariate data. Journal of the American Statistical Association 86, 108–113. L. (1986). A case–cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika 73, 1–11. L. (1989). Surrogate endpoints in clinical trials: Discussion, deﬁnition and operational criteria.
A total of 10 labs across the United States are applying various proteomic platforms for shared discovery analyses, under the auspices of the NCI’s Early Detection Research Network and WHI. The other two CT components involve a low-fat dietary pattern for cancer prevention (48,835 women) and calcium and vitamin D supplementation for fracture prevention (36,282 women). , 2006, for the calcium and vitamin D trial), with much further analytic work, and explanatory analyses underway. Biomarker studies are underway in both the dietary modiﬁcation trial cohort and the OS to examine the measurement properties of frequencies, records, and recalls for self-reporting both dietary consumption and physical activity patterns.
This approach makes use of the fact that segments of the chromosome are inherited intact so that markers over some distance on a chromosome from a disease gene can be expected to associate with disease risk. , Ott, 1991; Thomas, 2004). Following the identiﬁcation of a linkage signal, some form of ﬁner mapping is needed to close in on disease-related loci. , Felsenstein, 1992). Hence, if a dense set of genetic markers is available across the genome, linkage analysis may give way to linkage-disequilibrium (LD) analyses.